Sanjevani HistaPlus Formula

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Sanjevani Histaplus is our new improved formula provides synergistic compounds that work together to provide optimum allergy and immune support. Quercetin, a beneficial plant bioflavanoid compound along with Dihydroquercetin (the newer bioavailable form) and Rutin, may be especially supportive of healthy immune responses during exposure to allergenic substances or irritants and chronic health conditions.  Further addition of Stinging Nettle, Bromelain and N-Acetyl L-Cysteine provides even more inflammatory and anti-histamine supportive benefits.

Sanjevani HistaPlus formula provides a natural approach to support immune system function by boosting antioxidant activity, favorably modulating inflammatory responses due to allergy, and enhancing immune responsiveness.

The ability of the immune system to recognize friend from foe and respond with an appropriate and effective defense is critical to optimal health. The body’s inflammatory response and antioxidant mechanisms are also vital to wellness and a healthy immune system. Inflammation is a normal response after exposure to allergens or irritants. However, if the inflammation is not properly regulated, it can produce damage to tissues and slow down the body’s normal healing and repair processes. Environmental and metabolic stressors can also promote inflammation and generate potentially damaging free radicals that can overwhelm the body’s antioxidant defenses. 

Sanjevani Histaplus provides these key ingredients:

Quercetin is a water-soluble bioflavonoid compound found in kale, onions, apples, green tea and black tea. Bioflavonoids are a diverse group of similarly structure compounds with extremely valuable antioxidant activity and other important functions. Quercetin has a potent antioxidant activity and helps stabilize cell membranes, which helps to protects the cells and tissues from the damaging effects of free radicals and excessive inflammation. It has also been shown to support histamine metabolism and modulate the activity of certain inflammation-promoting compounds. This works similar to Claritin, Zyrtec and Allegra without any side effects.

Vitamin C (ascorbic acid) is essential to humans and must be obtained exogenously. While most mammals are able to synthesize ascorbic acid, humans lack one of the enzymes required for this process and can quickly become deficient if dietary or supplemental intake is inadequate. Stress, smoking, pollution, and temperature changes increase our requirement for vitamin C. Well-known functions of vitamin C include antioxidant protection from damaging free radicals and the synthesis of collagen, carnitine, and neurotransmitters. Vitamin C also plays a lesser-known role in the deactivation of histamine.

Bioflavonoids Quercetin, dihydroquercetin (DHQ), and rutin are active bioflavonoids incorporated into HistaPlus Formula for their role in moderating an exaggerated immune response. Bioflavonoids work synergistically with other antioxidants to protect tissues from the negative effects of oxidation and inflammation often observed during hyperimmune reactions. Immune- moderating effects include inhibition of mast-cell degranulation and prevention of histamine release during hypersensitive episodes.

Rutin A source of naturally occurring flavonoids, rutin reduces capillary permeability and edema, which can reduce mucus fluid buildup or “runny nose." Rutin’s protective effect against oxidation is amplified by ascorbic acid, also present in HistaPlus Formula.

N-Acetyl-Cysteine is the acetylated form of the conditionally essential amino acid L-cysteine. As a precursor to the “master antioxidant” glutathione, NAC plays a significant role in detoxification and antioxidant protection. NAC also functions as a natural mucolytic, reducing the viscosity of mucus commonly produced during a hyperimmune response.

Stinging Nettle Extract (Urtica dioica) Stinging nettle leaf has been found to regulate a variety of inflammatory activities associated with hyperimmune response, including mast-cell degranulation, prostaglandin formation, and histamine action.

Bromelain refers to an enzyme complex extracted from the stem and fruit of the pineapple plant (Ananas comosus). Its modulation of the inflammatory response is thought to exert a beneficial effect in combating hypersensitive immune reactions, earning it approved status by the German Commission E for “micro-inflammations” and related discomforts. Early studies identified its positive effects on controlling edema, tissue permeability, and vasodilation. Bromelain is also found to enhance the absorption of quercetin.

Supplement Facts
Serving Size: 2 Capsules
Servings per Container: 30
  Amount Per Serving % Daily Value
Vitamin C (ascorbic acid) 200 mg 222%
Quercetin (as quercetin anhydrous)(derived from fava d’anta tree)(Dimorphandra mollis)(flower bud extract) 400 mg **
Stinging Nettle Aqueous Extract (Urtica dioca)(aerial parts)(1% silica) 200 mg **
Bromelain (2400 GDU/g)(from Ananas comosus)(stem) 100 mg **
Rutin (as rutin trihydrate)(derived from Japanese pagoda tree) (Sophora japonica)(flower bud extract) 100 mg **
N-Acetyl-L-Cysteine 100 mg **
Dihydroquercetin 40 mg **
† Daily Value not established

Other Ingredients: HPMC (capsule), dicalcium phosphate, stearic acid, magnesium stearate, silica, and medium-chain triglyceride oil.

Allergy Statement

Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soybeans. Contains no artificial colors, flavors, or preservatives.

Suggested Use

For immune support: 1 capsule twice daily with food or as directed by your healthcare provider. For allergy support: 1 capsule daily to twice daily with food as needed.


Keep closed in a cool, dry place out of reach of children.


If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product. Keep out of reach of children.

FDA Notice

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.