Ultimate Glucosamine Wellesley Therapeutics N-Acetyl-d-Glucosamine

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ULTIMATE GLUCOSAMINE contains only 100% pure N-acetylglucosamine.  It is free of additives, salts or preservatives, and contains more of the biologically active ingredient. Ultimate Glucosamine is the most direct route to the important macromolecules such as hyaluronic acid, keratan sulfate and chondroitin sulfate.  Ultimate Glucosamine does not interfere with glucose metabolism.

There are no known interactions with prescription medications, nor is there evidence of any specific side effects attributable to ULTIMATE GLUCOSAMINE. Still, you should always make your health care professional aware of all supplements you are taking.

  • 2000 mg of 100% N-Acetyl-D-Glucosamine per serving.
  • N-acetylglucosamine is a natural substance extracted from the shell of crustaceans.
  • Unlike many other natural products, NAG is known for its inherent sweet flavor.
  • Cartilage metabolism support may aid in long-term joint health.
  • Does not interfere with glucose metabolism
  • Free of additives, salts, preservatives, coloring agents, gluten, lactose or yeast.
  • 30 servings per container.

Diagram depicting the importance of cartilage in healthy joints. Serves as a cushion to prevent friction between bones.

N-Acetyl D-Glucosamine vs Glucosamine Sulfate

Glucosamine is a highly common supplemental ingredient for supporting healthy skin and joints. The supplement market is littered with products which feature this compound in its sulfate form, most typically alongside a similar compound known as Chondroitin. While these products may provide their own distinct advantages, and the synergistic relationship between Glucosamine and Chondroitin is well-documented, Ultimate Glucosamine from Wellesley Therapeutics is a very different supplement.

The first factor which distinguishes Ultimate Glucosamine from others is the form of Glucosamine which is used – N-Acetyl-D-Glucosamine (NAG). While NAG may share a lot of similarities with Glucosamine Sulfate, they are actually very different compounds with different potential effects and benefits within the human body.

One study which compared their effects concluded that NAG “likely exhibits a potential effect on the cartilage metabolism at a lower dose (500–1,000 mg/day) compared with glucosamine (1,500 mg/day), based on the present and previous results”. Meanwhile, some studies indicate that Glucosamine Sulfate is more likely to have an anti-inflammatory effect on joints and other parts of the human body.

Therefore, it may be discerned that Glucosamine Sulfate is best used to counter aches and pains in the joints, while NAG may be used to support cartilage metabolism in otherwise healthy individuals, thereby potentially reducing the risk of such aches and pains occurring in the first place.

While the contrasting effects of these ingredients are still being untangled, what’s certain is that there are strong differences in the way the body processes them. This includes their uptake, as well as their subsequent effects on glucose transport, GLUT expression and SGAG and hyaluronan synthesis. As such, those who have failed to experience results from Glucosamine Sulfate may have a different experience from NAG supplementation.

Supplement Facts
Serving Size: 1 Teaspoon
Servings per Container: 30
  Amount Per Serving % Daily Value
Calories 8  
N-Acetyl-D-Glucosamine 2 grams*
† Daily Value not established
Suggested Use

Take 1 scoop daily with a beverage or as directed by a healthcare practitioner. 


Glucosamine is a highly common supplemental ingredient for supporting healthy skin and joints


If you are pregnant or nursing, have a medical condition, or are taking medication, consult your healthcare professional before using this or any supplement. Discontinue use if allergic reaction occurs.

FDA Notice

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.