Sanjevani HistaPlus

Sanjevani HistaPlus™ – Natural Histamine Support for Seasonal and Environmental Wellness

If you’re seeking effective, natural relief from seasonal allergies, sinus issues, or environmental sensitivities, Sanjevani HistaPlus™ is your go-to solution. Formulated by renowned integrative medicine expert Dr. Sunil Pai, this advanced formula provides comprehensive histamine support through a synergistic blend of botanicals and antioxidants designed to stabilize mast cells, reduce inflammation, and protect your respiratory and immune health.

More than just a symptom reliever, HistaPlus™ addresses the underlying biological responses involved in histamine release making it ideal for those suffering from allergies, sensitivities, or histamine intolerance.

Sanjevani Histaplus is our 2025 new improved formula - Quercetin is scientifically formulated to support the respiratory system, including nasal passages. After several months of trying an ingredient that the industry has promoted as higher absorbable (Quercetin Phytosome), Dr. Pai was skeptical at its benefits as “increased absorption does not necessarily equal better efficacy”.  After months of trying the quercetin phytosome on hundreds of patients and himself, the lab data and patient response confirmed what Dr. Pai was concerned about.  The industry has marketing something, providing less dosage of the ingredients (to increase their profit margins) and claiming better absorption is only needed.  But clinically that is not what happens. It turns out to be just fancy marketing and Dr. Pai was correct to begin with.  Therefore, Dr. Pai had to find a contract manufacturer who doesn’t carry the quercetin phytosome (which is hard since almost all manufacturers have switched to the trendy but not effective quercetin phytosome).

The most effective form of quercetin is the traditional form derived from Sophora japonica. Delivered at clinical doses is what is provided in this new improved formula.  The results are improved when synergistic combined with Rosemary Extract and NAC to target inflammation, histamine and immune-system−related pathways connected to allergy and respiratory symptoms.

Sanjevani HistaPlus formula is a natural approach to support immune system function by boosting antioxidant activity, favorably modulating inflammatory responses due to allergy, and enhancing immune responsiveness. HistaPlus provides a clinically effective natural allergy support formula and is a better choice than taking OTC antihistamines like loratadine, cetirizine, fexofenadine, and diphenhydramine which have been shown to contribute to cognitive problems when chronically used in addition to common side effects such a drowsiness, fatigue, headache and dry mucous membranes.

The ability of the immune system to recognize friend from foe and respond with an appropriate and effective defense is critical to optimal health. The body’s inflammatory response and antioxidant mechanisms are also vital to wellness and a healthy immune system. Inflammation is a normal response after exposure to allergens or irritants. However, if the inflammation is not properly regulated, it can produce damage to tissues and slow down the body’s normal healing and repair processes. Environmental and metabolic stressors can also promote inflammation and generate potentially damaging free radicals that can overwhelm the body’s antioxidant defenses. 

Sanjevani Histaplus provides these key ingredients:

Quercetin is a water-soluble bioflavonoid compound found in kale, onions, apples, green tea and black tea. Bioflavonoids are a diverse group of similarly structure compounds with extremely valuable antioxidant activity and other important functions. Quercetin has a potent antioxidant activity and helps stabilize cell membranes, which helps to protects the cells and tissues from the damaging effects of free radicals and excessive inflammation. It has also been shown to support histamine metabolism and modulate the activity of certain inflammation-promoting compounds. Quercetin is a natural flavonoid found in many fruits and vegetables, known for its antioxidant, anti-inflammatory, antiviral, and immune-supporting properties. One of the most common and potent sources of quercetin used in dietary supplements is Sophora japonica, also known as the Japanese pagoda tree, a plant native to East Asia and traditionally used in Chinese medicine. The flowers and buds of Sophora japonica are particularly rich in quercetin and rutin, making them ideal for standardized supplement formulations.

Quercetin extracted from this plant is commonly used to help with allergy relief (by inhibiting histamine release), immune system modulation, reducing inflammation, supporting cardiovascular health, and protecting cells from oxidative stress. Additionally, it has been shown to improve memory and learning as well as stimulate neurogenesis, beta amyloid reduction and improve neuroplasticity and protects brain cells from damage.  While generally well-tolerated, quercetin may interact with certain medications such as antibiotics or blood thinners and should be used cautiously by pregnant or breastfeeding individuals or those taking prescription drugs. Quercetin at clinical doses of 1,000 mg/day is provide in Histaplus for maximum benefits.

Rosemary Extract 6% Rosmarinic Acid is a highly concentrated form of the rosemary plant (Rosmarinus officinalis), standardized to contain 6% rosmarinic acid, one of its primary bioactive compounds that makes rosemary effective. This extract is valued for its potent antioxidant, anti-inflammatory, antimicrobial, and neuroprotective properties. Rosmarinic acid helps neutralize free radicals, reduce inflammation, and support immune and cognitive health. Most products use generic rosemary extract that is not standardized to any rosmarinic acids. Thus, they can provide high amounts in milligrams on the label to make it sound stronger, but they have less potency of the herb since its not standardized, hence lower efficacy. Rosemary standardized to 6% Rosmarinic Acid and provided at the clinical doses of 300 mg per day, makes Histaplus highly effective. 

N-Acetyl-L-Cysteine is the acetylated form of the conditionally essential amino acid L-cysteine. NAC also functions as a natural mucolytic, reducing the viscosity of mucus commonly produced during a hyperimmune response. This helps with thinning mucous production and provides improved breathing response. As a precursor to the “master antioxidant” glutathione, NAC plays a significant role in detoxification and antioxidant protection, especially in the liver where it helps with histamine metabolism, regulation and clearance from the bloodstream.

What Makes HistaPlus™ Different?

Unlike typical antihistamines that can cause drowsiness or dryness, Sanjevani HistaPlus™ offers non-drowsy, natural support that works with your body, not against it. By combining high-potency quercetin, rosemary extract, and N-acetyl-L-cysteine (NAC), this formula calms the immune response, enhances antioxidant defenses, and supports detoxification pathways, all of which are crucial for those sensitive to histamine or prone to allergic reactions.

Key Benefits of Sanjevani HistaPlus™

️ Supports Respiratory Health and Sinus Comfort

High dose quercetin from Sophora japonica acts as a natural mast cell stabilizer, helping reduce the release of histamine and inflammatory cytokines that trigger sneezing, congestion, itchy eyes, and sinus pressure. This powerful bioflavonoid is especially helpful for people with chronic rhinitis, hay fever, or asthma-related sensitivities.

️Helps Regulate Histamine Response

Histamine overload can result from diet, environment, or impaired detoxification. With a therapeutic dose of 1,000 mg of quercetin per 4 capsules, HistaPlus™ helps regulate histamine release naturally, making it ideal for people with histamine intolerance, MCAS (mast cell activation syndrome), or food-related sensitivities.

Reduces Inflammation and Immune Overactivity

Rosemary Extract (6% Rosmarinic Acid) is a potent anti-inflammatory and antioxidant compound shown to modulate immune function and ease allergic symptoms. It works in harmony with quercetin to provide broad-spectrum immune support and reduce the oxidative stress associated with chronic allergies and inflammation.It also helps with memory and cognitive function unlike OTC and Rx antihistamines which have been shown to worsen cognitive function over time.

Detoxifies and Protects Cells with NAC

N-Acetyl-L-Cysteine (NAC) is a powerful antioxidant and precursor to glutathione, the body’s master detoxifier. NAC helps break down excess mucus, supports liver detox pathways, and protects cells from the oxidative damage triggered by histamine and inflammation. This makes it especially beneficial for long-term allergy sufferers or those with compromised detoxification function.

Improves Memory, Learning and beta amyloid reduction

Quercetin, Rosemary (6% Rosmarinic acid) and NAC have been shown to help with cognitive function and help stimulate neuronal growth, prevent damage from beta amyloid and lower inflammation in the brain.

Non-Drowsy, Fast-Acting Relief

Unlike pharmaceutical antihistamines that can cause fatigue or fogginess, HistaPlus™ provides symptom relief without sedation, making it suitable for daily use, at home, at work, or on the go.

Free From:

• Gluten
• Dairy
• Soy
• GMOs
• Artificial preservatives, colors, or flavors
• Common allergens

Who Can Benefit from Sanjevani HistaPlus™?

• People with seasonal allergies, hay fever, or sinus congestion
• Those with histamine intolerance or Mast Cell Activation Syndrome (MCAS)
• Individuals exposed to mold, environmental toxins, or airborne pollutants
• Patients seeking immune modulation and inflammation relief
• Those with chronic hives, skin irritation, or food-related sensitivities
• Anyone looking for non-drowsy allergy relief without synthetic drugs
• Those who need additional support with learning, memory and cognitive function

Breathe Easier, Live Clearer, Feel Better – Naturally

Whether you're battling seasonal triggers or managing long-term sensitivities, Sanjevani HistaPlus™ gives you the tools to take back control of your health, without compromise. Support your body’s natural defenses, stabilize immune function, and reduce histamine-driven symptoms with this professional-grade, integrative solution.

Say goodbye to constant sneezing, sinus pressure, and histamine overload and hello to clear breathing, clear thinking, and greater vitality.

Other Ingredients:

May include Microcrystalline Cellulose (USP) as a filler if necessary. Vegan Capsules (cellulose, purified water). 

No artificial colors, artificial flavors, milk or milk derivatives, or sodium added.

Allergy Statement

Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.

Suggested Use

Adults: 1-2 capsules twice daily with food or as directed by your healthcare provider. For allergy support: 1 capsule daily to twice daily with food as needed.

Note

Keep closed in a cool, dry place out of reach of children.

Warnings

If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product. Keep out of reach of children.

FDA Notice

^†*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.