MICROBIOME LABS Mega Sporebiotic

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MegaSporeBiotic™ is a 100% spore-based, broad-spectrum probiotic clinically shown to maintain healthy gut barrier function.

MegaSporeBiotic™ is a probiotic blend of 5 Bacillus spores that have been clinically shown to maintain healthy gut barrier function and overall immunity. The bi-phasic life cycle of the Bacillus spores allows them to remain dormant in harsh environments until they reach more favorable environments like the human gastrointestinal tract. Once inside the large intestine, these dormant spores can change into their active, vegetative forms and begin colonizing in the gut. This unique probiotic blend aims to RECONDITION the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut bacteria. MegaSporeBiotic™ boasts a 5-year shelf-life, does not require refrigeration, and maintains efficacy during antibiotic therapy.

Mega Sporebiotic Ingredients:

  • Bacillus Licheniformis: Produces proteases needed for protein digestion. Produces full spectrum of B vitamins.
  • Bacillus Indicus HU36™: Produces RDA levels of carotenoids: lycopene, astaxanthin, beta-carotene, and lutein. Produces quinols and vitamins.
  • Bacillus Subtilis HU58™: Produces nattokinase and vitamin K2. Supports healthy GALT development.
  • Bacillus Clausii: Supports immune function. Maintains efficacy during antibiotic treatment.
  • Bacillus Coagulans: Produces L+ optical form of lactic acid. Supports immune function.


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RHEE KJ, SETHUPATHI P, DRIKS A, ET AL.Role of commensal bacteria in development of gut-associated lymphoid tissue and preimmune antibody repertoire. J Immunol. 2004;172(2):1118-24.

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LEFEVRE M, RACEDO SM, RIPERT G, ET AL.Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study. Immun Aging. 2015;12:24.

SERRA CR, EARL AM, BARBOSA TM, ET AL.Sporulation during Growth in a Gut Isolate of Bacillus subtilis. J Bacteriol. 2014;196(23):4184-4196.

HONG HA, KHANEJA R, TAM NMK, ET AL.Bacillus subtilis isolated from the human gastrointestinal tract. Res Microbiol. 2009;160(2):134-143.

MANDEL DR, EICHAS K, HOLMES J. Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial. BMC Complement Altern Med. 2010;10:1.

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Supplement Facts
Serving Size: 2 Capsules
Servings per Container: 30
  Amount Per Serving % Daily Value
Proprietary Probiotic Blend 295 mg
4 Billion CFU
    Bacillus indicus, HU36™  
    Bacillus subtilis, HU58™  
    Bacillus coagulans (SC-208)  
    Bacillus licheniformis (SL-307)  
    Bacillus clausii (SC-109)  
† Daily Value not established

Other Ingredients: Cellulose, vegetable capsule (cellulose and water)

Suggested Use

Start with 1/2 capsule or 1 full capsule with food and slowly increase to 2 capsules per day using the following protocol. If 1 capsule every other day is too strong, try starting with 1/2 capsules or even 1/4 capsule in some cases. Possible symptoms may include abdominal cramping, loose stools, and changes in bowel movements. Though these symptoms may be uncomfortable, they are a sign that the product is working! Symptoms should resolve within 2-3 days.


Recommended to use AFTER treatment of SIBO and "leaky gut" along with Sanjevani Complete Probiotic Formula Powder or Sanjevani Complete Probiotic Formula Capsules.


If you are pregnant or nursing, have a medical condition, or are taking medication, consult your healthcare professional before using this or any supplement. Discontinue use if allergic reaction occurs.

FDA Notice

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.