Sanjevani Berberine Advanced - DHB

Introducing the enhanced Sanjevani Berberine Advanced - DHB, now more powerful than ever!

Sanjevani Berberine Advanced - DHB features dihydroberberine (DHB), a highly bioavailable metabolite of berberine with demonstrated benefits for blood glucose metabolism. Berberine naturally occurs in several plant species used extensively in traditional Ayurvedic and Chinese herbal practices; DHB is the natural bioactive form of berberine.

• Supports Enhanced Berberine Activity
• Supports Healthy Blood Glucose Metabolism

Sanjevani Nutraceuticals/ Cosmeceuticals ’s Berberine Advanced - DHB contains DHB originating from berberine sourced from Berberis aristata and naturally extracted through an enzymatic process similar to that which occurs in the human gut. With a 5-fold relative increase in absorption rate, supplemental DHB at much lower doses than berberine has comparable beneficial metabolic effects.

Clinical Applications

Sanjevani Berberine Advanced - DHB, an alkaloid extracted from various plants and traditionally utilized in Ayurveda and traditional Chinese medicine, holds a rich history of therapeutic applications. Contemporary clinical research, including in vivo, in vitro, and animal studies, reveals that dihydroberberine (DHB), a metabolite of berberine, surpasses its predecessor in bioavailability, providing superior support for maintaining healthy blood glucose levels.

Although the exact ways in which berberine benefits health aren't fully clear, it's believed that one mechanism involves influencing gut microbes, which in turn affects blood sugar levels. Studies on animals and cells suggest that berberine impacts glucose and fat metabolism through various pathways like AMPK, JNK, and PPAR-alpha. Activation of the AMPK pathway promotes glucose uptake and fat burning while reducing fat production and sugar formation. Berberine may also regulate pancreatic beta cell function and decrease glucose production by inhibiting certain enzymes in the gut.

Recent findings suggest that gut bacteria play a key role in how berberine works in the body. Berberine changes the types of bacteria in the gut and affects the substances they produce, which helps control how fats and sugars are processed. Also, gut bacteria convert berberine into its active form, DHB, which the intestines can absorb. After entering the bloodstream, DHB can change back into berberine.

Berberine absorption across the intestinal epithelia is suggested to be compromised because of its “flat” chemical configuration. Berberine displays poor bioavailability and increased potential for GI distress at the oral doses required to improve biomarkers associated with glucose homeostasis. The structure of the DHB derivative of berberine is comparably open, making it more amenable to uptake. To further explore the absorbability of berberine and DHB, researchers investigated the mechanism of action by which AMPK is activated and if using DHB at lower doses than berberine could potentially improve the effect on adiposity and glucose metabolism in rodents fed a high-fat diet. Berberine had to be administered at a nearly 5-fold increased dose of 560 mg/kg/d to establish the same effects demonstrated by DHB at 100 mg/kg/d. The rodents treated with the substantially lower dose of DHB showed markedly reduced adiposity and improved glucose tolerance. Additionally, insulin sensitivity was increased in the DHB-treated animals. These results led researchers to suggest that the difference in effects between berberine and DHB is due to the enhanced bioavailability of DHB. The findings of this study indicate that DHB delivers the beneficial metabolic effects of berberine in a more absorbable form and at a lower dose.

In a small study involving five participants, researchers compared how berberine and its derivative, DHB, are absorbed in the body. Participants took different doses of berberine and DHB over four days and had their blood tested regularly. They found that even smaller doses of DHB produced higher levels of berberine in the blood compared to larger doses of berberine itself. This indicates that DHB is more efficiently absorbed and leads to higher concentrations of berberine in the body compared to traditional berberine supplements.

Sanjevani Berberine Advanced - DHB supports healthy glucose metabolism for diabetes and cancer, helps maintains lipids in the normal range and provides SIBO/Candida/Gut Dysbiosis support. *

Sanjevani Berberine Advanced - DHB belongs to a class of naturally occurring alkaloids found in the roots, rhizomes, and stem bark of a number of plant species. Studies with berberine in people with diabetes show that it exerts multiple beneficial effects on glucose and lipid metabolism similar to metformin without negative effects.^†  Derived berberine is provided as berberine hydrochloride, the best studied form.

Sanjevani Berberine Advanced - DHB supports healthy glucose metabolism for diabetes and cancer, helps maintains lipids in the normal range and provides SIBO/Candida/Gut Dysbiosis support. *

Other Ingredients: Microcrystalline cellulose, vegetarian capsule (hydroxypropyl methylcellulose, water), stearic acid, and silicon dioxide.

Suggested Use

Take 2 capsules 1 to 2 times daily with food or as directed by your healthcare provider.

Note

It is recommended to have your HBA1c checked regularly if this is taken for blood glucose support and/or if taking this in addition to blood sugar medications.

Formulated to Exclude: Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

Warnings

If you are pregnant or nursing, have a medical condition, or are taking medication, consult your healthcare professional before using this or any supplement. Discontinue use if allergic reaction occurs.

FDA Notice

^†*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.